WebChemotype fingerprints (ToxPrints) Model NAM data, chemotypes and combination of both Evaluate different machine learning algorithms ----- Training set chemicals Training set chemicals 1. Chemicals with in vivo eco-data - from the EnviroTox1 database - 4016 2. Sub-selection for chemicals with NAM data (ToxCast and Tox21) - 1904 3. Web• 4825 Morgan + Torsion Topological + ToxPrints* (CA) • 2918 Gene + Morgan + Torsion Topological + ToxPrints (CBA) • Toxicity Outcomes extracted from ToxRefDB v2: • 922 target effects • 5 Liver specific target effects. Classification Approaches • Generalized Read Across (GenRA) [genra-py] • Artificial Neural Networks (ANN)
Read-Across Methodology in Toxicological Risk Assessment
WebTrax Print. Trax Print Provides Protection For Documents And Identification Both Digital And Printed, using a unique closed loop technology. Have your documents protected and … WebJan 15, 2024 · Technological advances in molecular biology have enabled high-throughput screening (HTS) of large chemical libraries. These approaches have provided valuable toxicity data for many physiological responses, including mitochondrial dysfunction. While several quantitative structure–activity relationship (QSAR) models have been developed … hb normal dan tidak normal
HumanExposure/qsur - Github
WebThe Library also incorporates the ToxServices’s Tolerable Intake (TI) database. This database comprises hundreds of chemical- and chemical group-specific TIs designed to … WebToxPrints: 792 “chemotype” features designed to cover environmental-exposure landscape (Yang et al., 2015) CERAPP: ~35K structures spannni g EDSP “unvi erse” and putative exposure landscape (Mansouri et al., 2016) FDA_Drugs: ~7K marketed & discontnuei d drugs BMDHHA: ~800 chemicals with benchmark dose human WebNov 1, 2024 · ToxPrints capture a broad diversity of chemical atom, bond, chain and scaffold types to represent chemical patterns and properties relevant to various toxicity … estbb jpo