Thioredoxin-interacting protein是什么
WebOct 21, 2024 · Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and … WebMar 3, 2024 · Thioredoxin-interacting protein (TXNIP) has emerged as an important factor in pancreatic beta cell biology, and tight regulation of TXNIP levels is necessary for beta cell survival. However, the ...
Thioredoxin-interacting protein是什么
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WebMay 6, 2024 · We identified thioredoxin-binding protein-2 (TBP-2) as a protein that interacts with thioredoxin, which is an important regulator of the cellular oxidation/reduction (redox) system (36, 55, 146). The redox-regulating activity of thioredoxin-interacting protein (Txnip) is one aspect of its function ( 108 , 182 ). WebMar 9, 2024 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction ...
WebJan 8, 2014 · One of the important endogenous molecules to interact with Trx is thioredoxin interacting protein (TXNIP, TBP2, VDUP1), which is a negative regulator of Trx function [56]. Cys63 and Cys247 in TXNIP can form the mixed disulfide bond with Trx active site thiols and suppress the activity of Trx and result in oxidative stress [57]. TXNIP is located ... WebAbstract. Thioredoxin (Trx) is an inflammation-inducible small oxidoreductase protein ubiquitously expressed in all organisms. Trx acts both intracellularly and extracellularly and is involved in a wide range of physiological cellular responses. Inside the cell, Trx alleviates oxidative stress by scavenging reactive oxygen species (ROS ...
WebThioredoxin protein has two cysteine residues in its active site that is a part of antioxidant system.. Thioredoxin system consists of Trx protein, thioredoxin reductase, NADPH coenzyme, and thioredoxin-interacting protein. • Trx system also plays a role in various biological functions such as regulation of apoptosis, redox regulation of transcription … WebMar 22, 2024 · Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein 2 (TBP-2)/vitamin D3up-regulated protein 1 (VDUP1), is an α-arrestin that can bind …
WebMay 15, 2024 · Thioredoxin-interacting protein (TXNIP), also known as vitamin D 3 up-regulated protein 1 (VDUP1) 1 or thioredoxin-binding protein-2 (TBP-2) 2, is a ubiquitously expressed protein with a molecular ...
WebMar 22, 2024 · Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein 2 (TBP-2)/vitamin D3up-regulated protein 1 (VDUP1), is an α-arrestin that can bind to and inhibit thioredoxin (the antioxidant protein). It was initially identified as a vitamin D3 target gene in the cancer cell line. The α-arrestins are known as ... gifts for the bicycle riderWebNov 30, 2024 · Thioredoxin interacting protein (Txnip) is an α-arrestin protein that regulates pleiotropic biological responses. Txnip acts as a cancer suppressor and is a critical regulator of energy metabolism. To investigate molecular mechanisms involving Txnip, we searched for its protein binding partners using tandem affinity purification and proteomics ... gifts for the beachWebNov 28, 2003 · Vitamin D 3-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin. J Biol Chem. 2002; 277: 26496–26500. Crossref Medline Google Scholar; 42 Watson WH, Pohl J, Montfort WR, Stuchlik O, Reed MS, Powis G, Jones DP. Redox potential of human thioredoxin 1 and … gifts for the birthday girl 22Trx1 has been shown to downregulate cardiac hypertrophy, the thickening of the walls of the lower heart chambers, by interactions with several different targets. Trx1 upregulates the transcriptional activity of nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and stimulates the expression of peroxisome … See more Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN … See more The primary function of Thioredoxin (Trx) is the reduction of oxidized cysteine residues and the cleavage of disulfide bonds. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, … See more Thioredoxin has been shown to interact with: • ASK1, • Collagen, type I, alpha 1, See more • RuBisCO - enzyme activity regulated by thioredoxin • Peroxiredoxin - enzyme activity regulated by thioredoxin See more They are found in nearly all known organisms and are essential for life in mammals. See more Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. … See more Thioredoxin is used in skin care products as an antioxidant in conjunction with glutaredoxin and glutathione. See more gifts for the blind elderlyWebNational Center for Biotechnology Information fsis sampling suppliesWebMar 9, 2024 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, … gifts for the bikerWebMar 21, 2024 · Thioredoxin-interacting protein (TXNIP, also called thioredoxin binding protein 2 or vitamin D upregulated protein), was originally identified as a negative regulator of thioredoxin which is a ... gifts for the bicyclist