WebOrigin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea. Function. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies ... The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of the pre-replication … See more Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea. See more ORC1 has been shown to interact with: • CDC45-related protein and • CDC6, • Cell division cycle 7-related protein kinase, See more • Overview of all the structural information available in the PDB for UniProt: Q13415 (Human Origin recognition complex subunit 1) at the See more • Gavin KA, Hidaka M, Stillman B (Dec 1995). "Conserved initiator proteins in eukaryotes". Science. 270 (5242): 1667–71. Bibcode:1995Sci...270.1667G. doi:10.1126/science.270.5242.1667. PMID 7502077. S2CID 43633493. • Ohtani K, DeGregori J, Leone … See more
研究报道人源DNA复制起始复合物ORC的冷冻电镜结构 - 生物研究 …
WebDec 9, 2024 · 人源orc有着更为复杂的功能调控机制:orc2-5四个亚基形成一个相对稳定的核心复合物,orc复合物组装到dna上依赖于orc1,orc1自身的蛋白水平以及orc1与 ... WebDec 30, 2024 · 体外研究表明,含h2a.z的核小体直接与组蛋白赖氨酸甲基转移酶suv420h1结合,促进了h4k20me2的沉积,而这又是orc1结合所必需的。 全基因组研究表明,来自h4k20me2、orc1和新生dna链的信号与h2a.z共定位,并且h2a.z的敲低导致整个基因组中h4k20me2、orc1和新生链信号的减少。 did atlanta win last nite
ORC1 origin recognition complex subunit 1 [ (human)]
WebNov 28, 2012 · 图解:A.酵母Orc1蛋白BAH结构域与Sir1蛋白的相互作用,相互作用部位集中在非保守的H domain及BAH loop区;B. 酵母Sir3蛋白BAH结构域与核小体复合体的晶体 … WebMar 21, 2024 · ORC1 (Origin Recognition Complex Subunit 1) is a Protein Coding gene. Diseases associated with ORC1 include Meier-Gorlin Syndrome 1 and Microtia . Among its … Webmln4924 处理,诱导衰老表型的特性,如放大和扁平的细胞形态,证明与衰老相关的β-gal 染色阳性。mln4924 诱导的衰老与细胞对 dna 损伤的反应相关,dna 损伤由 dna 沉默蛋白 cdt1 和 orc1 的积累导致,是 crl/scf e3s 失活的结果。mln4924 诱导的衰老是不可逆的,伴随着 city hall square apartments